YES
Definitely. You can build large Android apps using Python with absolute confidence. Even python can take care of the front end and backend of the app. Do not worry. Development in non-native language like Javaย orย Kotlin does not mean that the app will not look different or perform differently. There are great frameworks like Kivy and KivyMD . to make sure that the app will look like the native app. Tools like Python for android and Buildozer are available to convert the python code to an Full fledged Android App. Another best thing is you do not need Android studio to build these apps
Example Large Android Apps built using Python
These are available in Google Play store also